Description

Dacomitinib: Uses, Dosage, Side Effects & More

Dacomitinib is a prescription medication used for the treatment of non-small cell lung cancer (NSCLC). As a targeted therapy, it works by inhibiting specific proteins that help cancer cells grow and spread. Marketed under the brand name Vizimpro, Dacomitinib is approved for use in adults with EGFR-mutated NSCLC.

What is Dacomitinib?

Dacomitinib is an EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor. It is designed to block certain abnormal proteins in cancer cells that signal them to grow uncontrollably. By targeting these proteins, Dacomitinib helps slow or stop tumor growth.

Indications and Uses

Dacomitinib is used for:

• First-line treatment of patients with metastatic NSCLC that has EGFR exon 19 deletion or exon 21 (L858R) substitution mutations.

• It is suitable only for patients whose tumors have specific genetic mutations, confirmed by an FDA-approved test.

Dosage and Administration

• Recommended dosage: 45 mg taken orally once daily.

• Can be taken with or without food.

• Dose adjustments may be necessary based on side effects or liver function.

Note: Always follow your healthcare provider’s instructions regarding dosage.

Common Side Effects

Some of the most common side effects of Dacomitinib include:

• Diarrhea

• Rash and acne

• Dry skin

• Mouth sores

• Nail infections

• Loss of appetite

Serious side effects may include lung inflammation, severe diarrhea, and skin reactions. Contact your doctor if you experience symptoms like persistent cough, shortness of breath, or severe rash.

Warnings and Precautions

• Not recommended during pregnancy or breastfeeding.

• Can interact with other medications—inform your doctor about all drugs you are taking.

• Regular monitoring through blood tests and checkups is necessary during treatment.

Dacomitinib vs. Other EGFR Inhibitors

Compared to first-generation EGFR inhibitors like Erlotinib or Gefitinib, Dacomitinib has shown improved progression-free survival in certain patient groups, but it may also have more pronounced side effects. Your oncologist will choose the best treatment based on your cancer profile and overall health.

Frequently Asked Questions (FAQs)

Q: Is Dacomitinib a chemotherapy drug?
A: No, Dacomitinib is a targeted therapy, not traditional chemotherapy.

Q: How long can I take Dacomitinib?
A: Duration depends on your response to treatment and tolerance. Your doctor will guide your treatment plan.

Q: Does Dacomitinib cure cancer?
A: It is not a cure but can significantly slow down cancer progression and improve quality of life.

Where to Buy Dacomitinib?

Dacomitinib (Vizimpro) is available at specialty pharmacies and hospitals. Always ensure you purchase from a licensed and reputable source. A valid prescription is required.

Conclusion

Dacomitinib represents a significant advancement in the personalized treatment of EGFR-positive non-small cell lung cancer. While it offers improved outcomes for some patients, it should only be used under the guidance of a qualified healthcare provider. Always discuss the risks and benefits before starting treatment.