Description

What is Selinexor? Uses, Dosage, Side Effects & More

Selinexor is an FDA-approved prescription medication used primarily for the treatment of certain types of cancer, including multiple myeloma and diffuse large B-cell lymphoma (DLBCL). It belongs to a class of drugs known as selective inhibitors of nuclear export (SINE). Selinexor works by blocking a protein called XPO1, which plays a role in cancer cell survival.

Key Uses of Selinexor

Selinexor is commonly prescribed for:

• Relapsed or refractory multiple myeloma, often in combination with other medications like dexamethasone.

• Relapsed or refractory DLBCL, especially when other treatments have failed.

Doctors may also explore its use in clinical trials for other cancer types.

How Selinexor Works

Selinexor targets and inhibits exportin 1 (XPO1), a protein that helps transport tumor-suppressing proteins out of the cell nucleus. By blocking XPO1, Selinexor keeps these protective proteins inside the nucleus, restoring their cancer-fighting functions and slowing the growth of cancer cells.

Dosage and Administration

Selinexor is available in oral tablet form and is usually taken once or twice a week, depending on the prescribed regimen. Dosage may vary based on:

• Type of cancer

• Patient weight

• Combination with other therapies

• Overall health condition

Important: Always follow your healthcare provider’s instructions regarding dosage and scheduling.

Common Side Effects

Like all medications, Selinexor may cause side effects. The most commonly reported include:

• Fatigue

• Nausea and vomiting

• Loss of appetite

• Low blood counts (anemia, neutropenia, thrombocytopenia)

• Diarrhea

• Dizziness or confusion

Severe side effects should be reported to a doctor immediately.

Precautions and Warnings

Before taking Selinexor, discuss your full medical history with your doctor, especially if you have:

• Liver or kidney issues

• History of low blood cell counts

• Severe dehydration

Pregnant or breastfeeding women should avoid Selinexor, as it may harm the fetus or nursing baby.

Drug Interactions

Selinexor may interact with other drugs, including certain antifungals, antivirals, and chemotherapy agents. Provide your doctor with a complete list of all medications and supplements you are taking.

Final Thoughts

Selinexor is a breakthrough in targeted cancer therapy, especially for patients with limited treatment options. While it offers significant clinical benefits, it must be taken under strict medical supervision due to its potential side effects and drug interactions.