MAVIXEN 100MG/40MG – 21 TABS

MAVIXEN 100MG/40MG – 21 TABS

$1,941.46

Description

Glecaprevir and Pibrentasvir: A Breakthrough Treatment for Hepatitis C

Glecaprevir and Pibrentasvir are a powerful combination of antiviral medications used to treat chronic hepatitis C virus (HCV) infection in adults and children aged 3 years and older. Marketed under the brand name Mavyret, this fixed-dose combination therapy offers a highly effective, pangenotypic solution for most HCV genotypes (1 through 6).

What Are Glecaprevir and Pibrentasvir?

  • Glecaprevir is an HCV NS3/4A protease inhibitor.

  • Pibrentasvir is an HCV NS5A inhibitor.

Together, these direct-acting antivirals (DAAs) work by blocking the proteins essential for the replication of the hepatitis C virus, leading to viral clearance.

Key Benefits

  • High Cure Rates: Clinical trials have shown sustained virologic response (SVR) rates above 95%.

  • Short Treatment Duration: In many cases, just 8 weeks of therapy is sufficient.

  • Pangenotypic Coverage: Effective against all major HCV genotypes.

  • No Need for Ribavirin: Most patients do not require ribavirin or interferon.

  • Suitable for Patients with Renal Impairment and those who are treatment-naïve or experienced.

Indications

Glecaprevir/Pibrentasvir is indicated for:

  • Adults and pediatric patients ≥3 years with chronic HCV infection, genotypes 1–6

  • Patients without cirrhosis or with compensated cirrhosis (Child-Pugh A)

  • Certain patients with HIV/HCV co-infection

Dosage and Administration

Typically administered as 3 tablets once daily with food for 8 to 12 weeks, depending on the patient’s genotype, prior treatment history, and presence of cirrhosis.

Side Effects

Common side effects include:

  • Headache

  • Fatigue

  • Nausea

  • Diarrhea

Serious adverse effects are rare but may include liver problems, particularly in patients with underlying liver disease.

Drug Interactions

Glecaprevir/Pibrentasvir may interact with:

  • Rifampin

  • Carbamazepine

  • St. John’s Wort

  • Certain antiretroviral agents

A complete review of all medications and supplements with a healthcare provider is essential before starting treatment.

Why Choose Glecaprevir and Pibrentasvir?

As a highly effective, all-oral hepatitis C treatment, this medication has revolutionized care by offering:

  • Shorter duration

  • Fewer side effects

  • Broad genotype coverage

  • Convenience for patients


FAQ

Q: How effective is Glecaprevir/Pibrentasvir?
A: Over 95% of patients achieve a sustained virologic response, meaning the virus is undetectable after treatment.

Q: Can children take this medication?
A: Yes, it’s approved for use in children aged 3 and older.

Q: Do I need to fast before taking it?
A: No. In fact, it should be taken with food for optimal absorption.


Conclusion

Glecaprevir and Pibrentasvir provide a fast, safe, and highly effective way to treat hepatitis C. Whether you’re a healthcare professional or a patient seeking treatment, this combination therapy represents a major advance in HCV management.

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