Description

What Is Ivosidenib? Uses, Benefits, Side Effects & More

Ivosidenib (brand name: Tibsovo) is a prescription medication used in the treatment of certain types of cancer, particularly acute myeloid leukemia (AML) and cholangiocarcinoma. It belongs to a class of drugs known as IDH1 inhibitors, which target and block mutations in the IDH1 gene — a common mutation found in some cancer cells.

How Ivosidenib Works

Ivosidenib works by inhibiting the mutant isocitrate dehydrogenase 1 (IDH1) enzyme. In cancers where IDH1 is mutated, the enzyme produces an abnormal metabolite that blocks normal cell differentiation. By inhibiting this enzyme, Ivosidenib helps restore normal cell function and slows cancer growth.

FDA-Approved Uses of Ivosidenib

• Acute Myeloid Leukemia (AML): For adults with relapsed or refractory AML with an IDH1 mutation.

• Newly Diagnosed AML: For adults aged 75+ or those with comorbidities that prevent the use of intensive chemotherapy.

• Cholangiocarcinoma (bile duct cancer): For patients with locally advanced or metastatic IDH1-mutated cholangiocarcinoma who have been previously treated.

Key Benefits of Ivosidenib

• Targets cancer at the genetic level

• Offers a non-chemotherapy treatment option

• Oral medication — no infusion required

• Shown to improve overall survival in clinical trials

Common Side Effects

Like all medications, Ivosidenib may cause side effects. The most common include:

• Fatigue

• Nausea

• Diarrhea

• Joint pain

• QT prolongation (a heart rhythm condition)

• Increased white blood cell count (differentiation syndrome)

Always consult a healthcare provider for personalized medical advice and monitoring.

Who Should Take Ivosidenib?

Ivosidenib is intended for patients with confirmed IDH1 gene mutations. Genetic testing is required before starting treatment. It is most often prescribed by oncologists specializing in hematologic or gastrointestinal cancers.

Important Safety Information

Before using Ivosidenib:

• Discuss all medications with your doctor to avoid drug interactions.

• Inform your doctor of any heart conditions.

• Regular monitoring through blood tests and ECGs is necessary during treatment.

Ivosidenib Dosage & Administration

• Typically taken once daily by mouth

• Can be taken with or without food

• Patients should avoid grapefruit products and St. John’s Wort, which can affect drug levels

Conclusion

Ivosidenib (Tibsovo) represents a significant advancement in targeted cancer therapy, particularly for patients with IDH1-mutated AML and cholangiocarcinoma. If you or a loved one has been diagnosed with a cancer that may involve IDH1 mutations, talk to your oncologist about whether Ivosidenib is an appropriate treatment option.