Description

Enasidenib: Uses, Benefits, Dosage & Side Effects

Enasidenib (brand name: Idhifa) is an FDA-approved prescription medication used to treat relapsed or refractory acute myeloid leukemia (AML) in adults with an IDH2 gene mutation. It belongs to a class of drugs called isocitrate dehydrogenase-2 (IDH2) inhibitors, targeting cancer cells with specific genetic changes.

What is Enasidenib?

Enasidenib is an oral targeted therapy designed to inhibit the mutated IDH2 enzyme found in certain AML patients. This mutation leads to the production of abnormal cells, contributing to leukemia. By blocking IDH2, Enasidenib helps restore normal cell development and slow disease progression.

Indications and Uses

Enasidenib is primarily prescribed for:

• Adult patients with relapsed or refractory AML with an IDH2 mutation.

• Treatment is based on results from an FDA-approved diagnostic test to detect IDH2 mutations.

How Does Enasidenib Work?

In AML patients with IDH2 mutations, the mutated enzyme causes the accumulation of an oncometabolite called 2-hydroxyglutarate (2-HG), which blocks normal cell differentiation. Enasidenib inhibits this mutated enzyme, lowering 2-HG levels and allowing the bone marrow to produce healthy blood cells again.

Enasidenib Dosage and Administration

• Recommended dose: 100 mg orally once daily, with or without food.

• Continue until disease progression or unacceptable toxicity.

• Dose adjustments may be required based on side effects or liver function.

Note: Always follow your doctor’s exact dosage instructions.

Side Effects of Enasidenib

Common side effects may include:

• Nausea

• Vomiting

• Diarrhea

• Fatigue

• Jaundice (yellowing of the skin or eyes)

• Increased bilirubin levels

Serious side effects include:

• Differentiation Syndrome: A potentially life-threatening condition requiring immediate medical attention.

• Elevated liver enzymes

Seek medical help if you experience unexplained fever, difficulty breathing, rapid weight gain, or swelling.

Enasidenib Warnings and Precautions

• Regular monitoring of liver function and blood counts is essential.

• Not recommended during pregnancy or breastfeeding.

• Drug interactions may occur; inform your doctor of all medications and supplements.

Availability and Cost

Enasidenib (Idhifa) is available by prescription in tablet form. Cost may vary based on insurance coverage, location, and pharmacy. Patients may be eligible for financial assistance programs through the manufacturer or support organizations.